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tala fou

Faʻavaʻa

Melanoma faʻamatalaga mo na o le 4% o kanesa paʻu uma ae o loʻo i totonu o le sili ona faʻateʻaʻoti siama neoplasms. Dacarbazine o le vailaʻau filifilia mo le togafitia o melanoma i Pasila e ala i le lautele soifua maloloina faiga masani ona o lona tau maualalo. Peitai, o se alkylating sooupu o maualalo faʻapitoa ma elicits se togafitiga tali i na o 20% o mataupu. O isi vailaʻau o loʻo avanoa mo le togafitia o le melanoma e taugata tele, ma o sela tumo e masani ona teteʻe atu i nei vailaʻau. O le taua faasaga i le melanoma e manaʻomia ai se tala fou, e sili atu ona faʻapitoa vailaʻau e aoga i le fasiotia o fualaʻau faʻafomaʻi o loʻo teteʻe i vailaʻau. Dibenzoylmethane (1,3-diphenylpropane-1,3-dione) mafuaʻaga o loʻo folafolaina antitumor agents. I lenei suʻesuʻega, na matou suʻesuʻe ai i le aafiaga o le cytotoxic o le 1,3-diphenyl-2-benzyl-1,3-propanedione (DPBP) i luga o sela o le B16F10 melanoma faapea foi ma lona fesoʻotaʻiga tuusaʻo ma le molemole DNA e faʻaaoga ai vaʻaiga. Na faʻaalia e DPBP iʻuga lelei e faʻatatau i sela tuma ma sa iai le lisi filifilia o le 41.94. E le gata i lea, na matou faʻaalia foʻi le agavaʻa o le DPBP e fesoʻotaʻi saʻo ma le molemole DNA. O le mea moni e mafai e le DPBP ona faʻafesoʻotaʻi ma DNA in vitro faʻatagaina ai matou e faʻafesoʻotaʻia faapea o se fegalegaleaiga e ono tupu foi i totonu o le ola ma, o le mea lea, o le DPBP atonu o se isi auala e togafitia ai tagata mamaʻi i fualaʻau-faʻatonutonu melanomas. O nei sailiga e mafai ona taʻitaʻia le atinaʻeina o vailaʻau fou ma sili atu ona aoga.

Faʻamatalaga e le masani ai

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Fuafua o le pasene o le sela feoti maua mo DPBP lotoa faasaga melan-A ma B16F10 gafa i eseese concentrations. O le filifiliga filifilia (SI = IC50 melan-A / IC50 B16F10) sa 41.94.                    

Lolomiina e Elsevier BV

Faʻavaʻa

Dibenzoylmethane (DBM) o se tamaʻi sui o laisene ma se β-diketone faʻatusa o curcumin. O le fafagaina o le 1% DBM i le taumafataga i isumu Sencar i taimi uma na amataina ai ma taimi amata na amata ai ona matua taofia ai le 7,12-dimethylbenz [a] anthracene (DMBA) na faʻaosofia ai mammary tummy multiplicity ma mammary tumo na aʻafia i le 97%. I isi suʻesuʻega loloto e faʻaolaola ai auala talafeagai o le taofiofia o le gaioi o le DBM, fafagaina o le 1% DBM i le AIN-76A taumafataga i le matua matutua Sencar mo le 4-5 vaiaso paʻu le uterine susu mamafa i le 43%, taofia le faʻateleina fua faatatau o mammary gland epithelial sela e le 53%, uterine epithelium e le 23%, ma uterine stroma e le 77%, ina ua fasiotia isumu i le taimi o le estrus phase muamua o le taamilosaga o le taamilosaga. I se faʻaopopoga, fafagaina 1% DBM i le taumafataga i Sencar isumu i 2 vaiaso muamua, i le taimi ma le 1 vaiaso ina ua maeʻa DMBA togafitiga (faʻatupuina o le 1 mg DMBA i isumu taʻitasi vaiaso i le vaiaso mo 5 vaiaso) taofia faʻavae o le atoa DMBA – DNA faʻaopopo i mammary glands i le 72% faʻaaogaina o le post-32P-faʻaigoaina o le igoa. O le mea lea, o le fafagaina o le taumafataga 1% DBM i isumu Sencar na faʻalavelaveina ai le fausiaina o DMBA-DNA faʻaopoopoga i le susu mammary ma tuʻuina i lalo le fua faʻateleina o le susu mammary i vivo. Nei iʻuga ono faʻamatalaina le malosi taofiofi gaioiga o meaʻai DBM i mammary carcinogenesis i isumu.


Taimi Post: Aukuso-12-2020